Publications

Peer-reviewed articles

2026 3 papers

  1. A Zika virus vaccine with E protein fusion loop mutations protects via CD8+ T cells

    Kantinan Chuensirikulchai, Qin Hui Li, Hsueh-han Lu, Julia Timis, Manuel Montano, Luke Eder, Pradip Bhandari, Dawid S. Zyla, Maximilian Bunz, Henry Madany, Rubens Prince Dos Santos Alves, Paolla Beatriz Almeida Pinto, Erin Maule, Michael Nguyen, Erica Ollmann Saphire, Lakshmanane Premkumar, Annie Elong Ngono, Sujan Shresta

    Nature Microbiology · 2026 · 10.1038/s41564-026-02465-6 View paper

  2. Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins.

    Marissa Acciani, Dawid S. Zyla, Gele Niemeyer, Stephanie Harkins, Diptiben Parekh, Emily Pawlack, Davide Lacarbonara, Dhvanir Kansara, Margaret E. Ackerman, Stefan Niewiesk, Matteo Porotto, Kathryn M. Hastie, Erica Ollmann Saphire

    Cell host & microbe · 2026 · 10.1016/j.chom.2026.04.010 View paper

  3. Structural and mechanistic basis for antibody neutralization of the measles fusion protein

    Dawid S. Zyla, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer, Gillian Zipursky, Laura Di Clemente, Mare H. L. Verbruggen, Laura L. A. van Dijk, Oscar Martinez Ceh, Gabriella Jonathan-Trakht, Gavreel Kalantarov, Marissa Acciani, Giulia Laterza, Dariia Vyshenska, Cameron Leedale, Emily Pawlack, Kathryn M. Hastie, Branka Horvat, Rik L. de Swart, Rory D. de Vries, Alexander L. Greninger, Stefan Niewiesk, Erica Ollmann Saphire, Matteo Porotto

    Nature Communications · 2026 · 10.1038/s41467-026-71373-4 View paper

2025 3 papers

  1. How herpes is assembled

    Dawid S. Zyla

    eLife · 2025 · 10.7554/eLife.106419 View paper

  2. Human endogenous retrovirus K (HERV-K) envelope structures in pre- and post-fusion by cryo-EM

    Jeremy Shek, Chen Sun, Elise M. Wilson, Fatemeh Moadab, Kathryn M. Hastie, Roshan R. Rajamanickam, Patrick J. Penalosa, Stephanie S. Harkins, Diptiben Parekh, Chitra Hariharan, Dawid S. Zyla, Cassandra Yu, Kelly C. L. Shaffer, Victoria I. Lewis, Ruben Diaz Avalos, Tomas Mustelin, Erica Ollmann Saphire

    Science Advances · 2025 · 10.1126/sciadv.ady8168 View paper

  3. Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation.

    Eduardo Olmedillas, Roshan R. Rajamanickam, Ruben Diaz Avalos, Fernanda Ana-Sosa-Batiz, Dawid S. Zyla, Michelle A. Zandonatti, Stephanie S. Harkins, Sujan Shresta, Kathryn M. Hastie, Erica Ollmann Saphire

    Cell reports · 2025 · 10.1016/j.celrep.2025.116052 View paper

2024 3 papers

  1. A neutralizing antibody prevents postfusion transition of measles virus fusion protein

    Dawid S. Zyla, Roberta Della Marca, Gele Niemeyer, Gillian Zipursky, Kyle Stearns, Cameron Leedale, Elizabeth B. Sobolik, Heather M. Callaway, Chitra Hariharan, Weiwei Peng, Diptiben Parekh, Tara C. Marcink, Ruben Diaz Avalos, Branka Horvat, Cyrille Mathieu, Joost Snijder, Alexander L. Greninger, Kathryn M. Hastie, Stefan Niewiesk, Anne Moscona, Matteo Porotto, Erica Ollmann Saphire

    Science · 2024 · 10.1126/science.adm8693 View paper

  2. Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography.

    Reika Watanabe, Dawid S. Zyla, Diptiben Parekh, Connor Hong, Ying Jones, Sharon L. Schendel, William Wan, Guillaume Castillon, Erica Ollmann Saphire

    Cell · 2024 · 10.1016/j.cell.2024.08.044 View paper

  3. The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili.

    Dawid S. Zyla, Thomas Wiegand, Paul Bachmann, Rafal Zdanowicz, Christoph Giese, Beat H. Meier, Gabriel Waksman, Manuela K. Hospenthal, Rudi Glockshuber

    Nature communications · 2024 · 10.1038/s41467-024-47212-9 View paper

2023 2 papers

  1. Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence.

    Kathryn M. Hastie, Xiaoying Yu, Fernanda Ana-Sosa-Batiz, Dawid S. Zyla, Stephanie S. Harkins, Chitra Hariharan, Hal Wasserman, Michelle A. Zandonatti, Robyn Miller, Erin Maule, Kenneth Kim, Kristen M. Valentine, Sujan Shresta, Erica Ollmann Saphire

    Cell reports · 2023 · 10.1016/j.celrep.2023.112421 View paper

  2. Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus.

    Alex Moon-Walker, Zeli Zhang, Dawid S. Zyla, Tierra K. Buck, Haoyang Li, Ruben Diaz Avalos, Sharon L. Schendel, Kathryn M. Hastie, Shane Crotty, Erica Ollmann Saphire

    Cell chemical biology · 2023 · 10.1016/j.chembiol.2023.03.005 View paper

2022 2 papers

  1. A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus

    Haoyang Li, Tierra Buck, Michelle Zandonatti, Jieyun Yin, Alex Moon-Walker, Jingru Fang, Anatoliy Koval, Megan L. Heinrich, Megan M. Rowland, Ruben Diaz Avalos, Sharon L. Schendel, Diptiben Parekh, Dawid S. Zyla, Adrian Enriquez, Stephanie Harkins, Brian Sullivan, Victoria Smith, Onyeka Chukwudozie, Reika Watanabe, James E. Robinson, Robert F. Garry, Luis M. Branco, Kathryn M. Hastie, Erica Ollmann Saphire

    Science Translational Medicine · 2022 · 10.1126/scitranslmed.abq0991 View paper

  2. Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody.

    Heather M. Callaway, Dawid S. Zyla, Florence Larrous, Guilherme Dias de Melo, Kathryn M. Hastie, Ruben Diaz Avalos, Alyssa Agarwal, Davide Corti, Hervé Bourhy, Erica Ollmann Saphire

    Science advances · 2022 · 10.1126/sciadv.abp9151 View paper

2021 3 papers

  1. A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection.

    Anika Kuster, Nour L. Mozaffari, Oliver J. Wilkinson, Jessica L. Wojtaszek, Christina Zurfluh, Sara Przetocka, Dawid S. Zyla, Christine von Aesch, Mark S. Dillingham, R. Scott Williams, Alessandro A. Sartori

    Science advances · 2021 · 10.1126/sciadv.abc6381 View paper

  2. Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution

    Morgane Callon, Alexander A. Malär, Sara Pfister, Václav Římal, Marco E. Weber, Thomas Wiegand, Johannes Zehnder, Matías Chávez, Riccardo Cadalbert, Rajdeep Deb, Alexander Däpp, Marie-Laure Fogeron, Andreas Hunkeler, Lauriane Lecoq, Anahit Torosyan, Dawid S. Zyla, Rudolf Glockshuber, Stefanie Jonas, Michael Nassal, Matthias Ernst, Anja Böckmann, Beat H. Meier

    Journal of Biomolecular NMR · 2021 · 10.1007/s10858-021-00373-x View paper

  3. Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

    Kathryn M. Hastie, Haoyang Li, Daniel Bedinger, Sharon L. Schendel, S. Moses Dennison, Kan Li, Vamseedhar Rayaprolu, Xiaoying Yu, Colin Mann, Michelle Zandonatti, Ruben Diaz Avalos, Dawid S. Zyla, Tierra Buck, Sean Hui, Kelly Shaffer, Chitra Hariharan, Jieyun Yin, Eduardo Olmedillas, Adrian Enriquez, Diptiben Parekh, Milite Abraha, Elizabeth Feeney, Gillian Q. Horn, Yoann Aldon, Hanif Ali, Sanja Aracic, Ronald R. Cobb, Ross S. Federman, Joseph M. Fernandez, Jacob Glanville, Robin Green, Gevorg Grigoryan, Ana G. Lujan Hernandez, David D. Ho, Kuan-Ying A. Huang, John Ingraham, Weidong Jiang, Paul Kellam, Cheolmin Kim, Minsoo Kim, Hyeong Mi Kim, Chao Kong, Shelly J. Krebs, Fei Lan, Guojun Lang, Sooyoung Lee, Cheuk Lun Leung, Junli Liu, Yanan Lu, Anna MacCamy, Andrew T. McGuire, Anne L. Palser, Terence H. Rabbitts, Zahra Rikhtegaran Tehrani, Mohammad M. Sajadi, Rogier W. Sanders, Aaron K. Sato, Liang Schweizer, Jimin Seo, Bingqing Shen, Jonne L. Snitselaar, Leonidas Stamatatos, Yongcong Tan, Milan T. Tomic, Marit J. van Gils, Sawsan Youssef, Jian Yu, Tom Z. Yuan, Qian Zhang, Bjoern Peters, Georgia D. Tomaras, Timothy Germann, Erica Ollmann Saphire

    Science · 2021 · 10.1126/science.abh2315 View paper

2020 4 papers

  1. A metabolite binding protein moonlights as a bile‐responsive chaperone

    Changhan Lee, Patrick Betschinger, Kevin Wu, Dawid S. Zyla, Rudi Glockshuber, James CA Bardwell

    The EMBO Journal · 2020 · 10.15252/embj.2019104231 View paper

  2. Architecture and function of human uromodulin filaments in urinary tract infections

    Gregor L. Weiss, Jessica J. Stanisich, Maximilian M. Sauer, Chia-Wei Lin, Jonathan Eras, Dawid S. Zyla, Johannes Trück, Olivier Devuyst, Markus Aebi, Martin Pilhofer, Rudi Glockshuber

    Science · 2020 · 10.1126/science.aaz9866 View paper

  3. Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA

    Dawid S. Zyla, Blanca Echeverria, Rudi Glockshuber

    The Journal of biological chemistry · 2020 · 10.1074/jbc.ra120.014324 View paper

  4. The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

    Jessica J Stanisich, Dawid S. Zyla, Pavel Afanasyev, Jingwei Xu, Anne Kipp, Eric Olinger, Olivier Devuyst, Martin Pilhofer, Daniel Boehringer, Rudi Glockshuber

    eLife · 2020 · 10.7554/elife.60265 View paper

2019 1 paper

  1. Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria

    Dawid S. Zyla, Andrea E. Prota, Guido Capitani, Rudi Glockshuber

    Journal of Biological Chemistry · 2019 · 10.1074/jbc.RA119.008610 View paper

2017 1 paper

  1. The Cryoelectron Microscopy structure of the Type 1 Chaperone-Usher Pilus Rod

    Manuela K. Hospenthal, Dawid S. Zyla, Tiago R.D. Costa, Adam Redzej, Christoph Giese, James Lillington, Rudi Glockshuber, Gabriel Waksman

    Structure (London, England : 1993) · 2017 · 10.1016/j.str.2017.10.004 View paper

Preprints

Manuscripts posted to a preprint server and not yet published in a peer-reviewed journal.

2026 1 paper

  1. Antigenic landscape of rabies and related lyssaviruses revealed by cryo-EM

    Heather M. Callaway, Dawid S. Zyla, Kathryn M. Hastie, Stephanie S. Harkins, Shanika Kothalawalage, Nimasha Samarasinghe, Alexander Flynn, Chitra Hariharan, Jieyun Yin, Davide Corti, Herve Bourhy, Scott K. Dessain, Erica Ollmann Saphire

    Preprint bioRxiv · 2026 · 10.64898/2026.01.14.699513 View paper

2025 2 papers

  1. Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo

    Dawid S. Zyla, Gillian Zipursky, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer, Weiwei Peng, Camilla Predella, Kyle Stearns, Cameron Leedale, Jonathan Miller, Daniel Tay, Jonathan Kao, Marissa Acciani, Laura Di Clemente, Anirban Das, Diptiben Parekh, Ruben Diaz Avalos, Gael McGill, N Valerio Dorrello, Kathryn M Hastie, Christopher A Alabi, Joost Snijder, Anne Moscona, Alexander L. Greninger, Stefan Niewiesk, Erica Ollmann Saphire, Matteo Porotto

    Preprint bioRxiv · 2025 · 10.1101/2025.10.07.681039 View paper

  2. Uncovering the features of Measles-targeting human antibodies elicited by the MMR vaccine

    Marissa Acciani, Dawid S. Zyla, Gele Niemeyer, Stephanie Harkins, Diptiben Parekh, Emily Pawlack, Davide LaCarbonara, Stefan Niewiesk, Matteo Porotto, Kathryn M. Hastie, Erica Ollmann Saphire

    Preprint bioRxiv · 2025 · 10.1101/2025.09.09.675230 View paper