Publications

2026 2 papers

  1. Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins

    Marissa Acciani, Dawid Zyla, Gele Niemeyer, Stephanie Harkins, Diptiben Parekh, Emily Pawlack, Davide Lacarbonara, Dhvanir Kansara, Margaret E. Ackerman, Stefan Niewiesk, Matteo Porotto, Kathryn M. Hastie, Erica Ollmann Saphire

    Cell Host & Microbe · 2026 · 10.1016/j.chom.2026.04.010 View paper

  2. Structural and mechanistic basis for antibody neutralization of the measles fusion protein

    Dawid S. Zyla, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer, Gillian Zipursky, Laura Di Clemente, Mare H. L. Verbruggen, Laura L. A. van Dijk, Oscar Martinez Ceh, Gabriella Jonathan-Trakht, Gavreel Kalantarov, Marissa Acciani, Giulia Laterza, Dariia Vyshenska, Cameron Leedale, Emily Pawlack, Kathryn M. Hastie, Branka Horvat, Rik L. de Swart, Rory D. de Vries, Alexander L. Greninger, Stefan Niewiesk, Erica Ollmann Saphire, Matteo Porotto

    Nature Communications · 2026 · 10.1038/s41467-026-71373-4 View paper

2025 7 papers

  1. Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo

    Dawid S. Zyla, Gillian Zipursky, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer, Weiwei Peng, Camilla Predella, Kyle Stearns, Cameron Leedale, Jonathan Miller, Daniel Tay, Jonathan Kao, Marissa Acciani, Laura Di Clemente, Anirban Das, Diptiben Parekh, Ruben Diaz Avalos, Gael McGill, N Valerio Dorrello, Kathryn M Hastie, Christopher A Alabi, Joost Snijder, Anne Moscona, Alexander L. Greninger, Stefan Niewiesk, Erica Ollmann Saphire, Matteo Porotto

    bioRxiv · 2025 · 10.1101/2025.10.07.681039 View paper

  2. Structural and Mechanistic Basis for Antibody Neutralization of the Measles Fusion Protein

    Dawid S. Zyla, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer, Gillian Zipursky, Laura Di Clemente, Gabriella Jonathan-Trakht, Gavreel Kalantarov, Marissa Acciani, Giulia Laterza, Dariia Vyshenska, Kathryn M Hastie, Branka Horvat, Alexander L. Greninger, Stefan Niewiesk, Erica Ollmann Saphire, Matteo Porotto

    bioRxiv · 2025 · 10.1101/2025.09.11.675466 View paper

  3. Uncovering the features of Measles-targeting human antibodies elicited by the MMR vaccine

    Marissa Acciani, Dawid Zyla, Gele Niemeyer, Stephanie Harkins, Diptiben Parekh, Emily Pawlack, Davide LaCarbonara, Stefan Niewiesk, Matteo Porotto, Kathryn M. Hastie, Erica Ollmann Saphire

    bioRxiv · 2025 · 10.1101/2025.09.09.675230 View paper

  4. Human endogenous retrovirus K (HERV-K) envelope structures in pre- and post-fusion by cryo-EM

    Tomas Mustelin, Chitra Hariharan, Stephanie Harkins, Roshan Raj Rajamanickam, Kathryn Hastie, Diptiben Parekh, Chen Sun, Patrick Penalosa, Cassandra Yu, Elise Wilson, Ruben Diaz Avalos, Victoria Irene Lewis, Fatemeh Moadab, Jeremy Shek, Erica Ollmann Saphire, Dawid S Zyla, Kelly Christine Lee Shaffer

    Science Advances · 2025 · 10.1126/sciadv.ady8168 View paper

  5. Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation

    Eduardo Olmedillas, Roshan R. Rajamanickam, Ruben Diaz Avalos, Fernanda Ana-Sosa-Batiz, Dawid Zyla, Michelle A. Zandonatti, Stephanie S. Harkins, Sujan Shresta, Kathryn M. Hastie, Erica Ollmann Saphire

    Cell Reports · 2025 · 10.1016/j.celrep.2025.116052 View paper

  6. Human endogenous retrovirus K (HERV-K) envelope structures in pre- and post-fusion by Cryo-EM

    Jeremy Shek, Chen Sun, Elise M. Wilson, Fatemeh Moadab, Kathryn M. Hastie, Roshan R. Rajamanickam, Patrick J. Penalosa, Stephanie S. Harkins, Diptiben Parekh, Chitra Hariharan, Dawid S. Zyla, Cassandra Yu, Kelly C.L. Shaffer, Victoria I. Lewis, Ruben Diaz Avalos, Tomas Mustelin, Erica Ollmann Saphire

    bioRxiv · 2025 · 10.1101/2025.04.04.647320 View paper

  7. How herpes is assembled

    Dawid S Zyla

    eLife · 2025 · 10.7554/eLife.106419 View paper

2024 3 papers

  1. Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography

    Reika Watanabe, Dawid Zyla, Diptiben Parekh, Connor Hong, Ying Jones, Sharon L. Schendel, William Wan, Guillaume Castillon, Erica Ollmann Saphire

    Cell · 2024 · 10.1016/j.cell.2024.08.044 View paper

  2. A neutralizing antibody prevents postfusion transition of measles virus fusion protein

    Dawid S. Zyla, Roberta Della Marca, Gele Niemeyer, Gillian Zipursky, Kyle Stearns, Cameron Leedale, Elizabeth B. Sobolik, Heather M. Callaway, Chitra Hariharan, Weiwei Peng, Diptiben Parekh, Tara C. Marcink, Ruben Diaz Avalos, Branka Horvat, Cyrille Mathieu, Joost Snijder, Alexander L. Greninger, Kathryn M. Hastie, Stefan Niewiesk, Anne Moscona, Matteo Porotto, Erica Ollmann Saphire

    Science · 2024 · 10.1126/science.adm8693 View paper

  3. The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili

    Dawid S. Zyla, Thomas Wiegand, Paul Bachmann, Rafal Zdanowicz, Christoph Giese, Beat H. Meier, Gabriel Waksman, Manuela K. Hospenthal, Rudi Glockshuber

    Nature Communications · 2024 · 10.1038/s41467-024-47212-9 View paper

2023 4 papers

  1. Intracellular Ebola Virus nucleocapsid assembly revealed by in situ cryo-electron tomography.

    Reika Watanabe, Dawid Zyla, Diptiben Parekh, Connor Hong, Ying Jones, Sharon L. Schendel, Willian Wan, Guillaume Castillon, Erica Ollmann Saphire

    bioRxiv · 2023 · 10.1101/2023.12.01.569666 View paper

  2. Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence

    Hastie, K.M., Yu, X., Ana-Sosa-Batiz, F., Zyla, D.S., Harkins, S.S., Hariharan, C., Wasserman, H., Zandonatti, M.A., Miller, R., Maule, E., Kim, K., Valentine, K.M., Shresta, S., Saphire, E.O.

    Cell Reports · 2023 · 10.1016/j.celrep.2023.112421 View paper

  3. Potent, Omicron-Neutralizing Antibodies Isolated From a Patient Vaccinated 6 Months Before Omicron Emergence

    Hastie, K.M., Yu, X., Batiz, F.A.S., Zyla, D., Harkins, S.S., Hariharan, C., Wasserman, H., Zandonatti, M.A., Miller, R., Maule, E., Kim, K., Valentine, K., Shresta, S., Saphire, E.O.

    SSRN · 2023 View paper

  4. Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus

    Moon-Walker, A., Zhang, Z., Zyla, D.S., Buck, T.K., Li, H., Diaz Avalos, R., Schendel, S.L., Hastie, K.M., Crotty, S., Saphire, E.O.

    Cell Chemical Biology · 2023 · 10.1016/j.chembiol.2023.03.005 View paper

2022 3 papers

  1. A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus

    Haoyang Li, Tierra Buck, Michelle Zandonatti, Jieyun Yin, Alex Moon-Walker, Jingru Fang, Anatoliy Koval, Megan L. Heinrich, Megan M. Rowland, Ruben Diaz Avalos, Sharon L. Schendel, Diptiben Parekh, Dawid Zyla, Adrian Enriquez, Stephanie Harkins, Brian Sullivan, Victoria Smith, Onyeka Chukwudozie, Reika Watanabe, James E. Robinson, Robert F. Garry, Luis M. Branco, Kathryn M. Hastie, Erica Ollmann Saphire

    Science Translational Medicine · 2022 · 10.1126/scitranslmed.abq0991 View paper

  2. Structural basis for antibody-mediated neutralization of Lymphocytic choriomeningitis virus

    Alex Moon-Walker, Zeli Zhang, Dawid S. Zyla, Tierra K. Buck, Haoyang Li, Ruben Diaz Avalos, Sharon L. Schendel, Kathryn M. Hastie, Shane Crotty, Erica Ollmann Saphire

    bioRxiv · 2022 · 10.1101/2022.07.17.500368 View paper

  3. Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody

    Heather M. Callaway, Dawid Zyla, Florence Larrous, Guilherme Dias de Melo, Kathryn M. Hastie, Ruben Diaz Avalos, Alyssa Agarwal, Davide Corti, Hervé Bourhy, Erica Ollmann Saphire

    Science Advances · 2022 · 10.1126/sciadv.abp9151 View paper

2021 5 papers

  1. Structure of the rabies virus glycoprotein trimer bound to a pre-fusion specific neutralizing antibody

    Heather M. Callaway, Dawid Zyla, Kathryn M. Hastie, Ruben Diaz Avalos, Alyssa Agarwal, Hervé Bourhy, Davide Corti, Erica Ollmann Saphire

    bioRxiv · 2021 · 10.1101/2021.11.16.468852 View paper

  2. Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

    Kathryn M. Hastie, Haoyang Li, Daniel Bedinger, Sharon L. Schendel, S. Moses Dennison, Kan Li, Vamseedhar Rayaprolu, Xiaoying Yu, Colin Mann, Michelle Zandonatti, Ruben Diaz Avalos, Dawid Zyla, Tierra Buck, Sean Hui, Kelly Shaffer, Chitra Hariharan, Jieyun Yin, Eduardo Olmedillas, Adrian Enriquez, Diptiben Parekh, Milite Abraha, Elizabeth Feeney, Gillian Q. Horn, Yoann Aldon, Hanif Ali, Sanja Aracic, Ronald R. Cobb, Ross S. Federman, Joseph M. Fernandez, Jacob Glanville, Robin Green, Gevorg Grigoryan, Ana G. Lujan Hernandez, David D. Ho, Kuan-Ying A. Huang, John Ingraham, Weidong Jiang, Paul Kellam, Cheolmin Kim, Minsoo Kim, Hyeong Mi Kim, Chao Kong, Shelly J. Krebs, Fei Lan, Guojun Lang, Sooyoung Lee, Cheuk Lun Leung, Junli Liu, Yanan Lu, Anna MacCamy, Andrew T. McGuire, Anne L. Palser, Terence H. Rabbitts, Zahra Rikhtegaran Tehrani, Mohammad M. Sajadi, Rogier W. Sanders, Aaron K. Sato, Liang Schweizer, Jimin Seo, Bingqing Shen, Jonne L. Snitselaar, Leonidas Stamatatos, Yongcong Tan, Milan T. Tomic, Marit J. van Gils, Sawsan Youssef, Jian Yu, Tom Z. Yuan, Qian Zhang, Bjoern Peters, Georgia D. Tomaras, Timothy Germann, Erica Ollmann Saphire

    Science · 2021 · 10.1126/science.abh2315 View paper

  3. Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution

    Morgane Callon, Alexander A. Malär, Sara Pfister, Václav Římal, Marco E. Weber, Thomas Wiegand, Johannes Zehnder, Matías Chávez, Riccardo Cadalbert, Rajdeep Deb, Alexander Däpp, Marie-Laure Fogeron, Andreas Hunkeler, Lauriane Lecoq, Anahit Torosyan, Dawid Zyla, Rudolf Glockshuber, Stefanie Jonas, Michael Nassal, Matthias Ernst, Anja Böckmann, Beat H. Meier

    Journal of Biomolecular NMR · 2021 · 10.1007/s10858-021-00373-x View paper

  4. A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection

    Anika Kuster, Nour L. Mozaffari, Oliver J. Wilkinson, Jessica L. Wojtaszek, Christina Zurfluh, Sara Przetocka, Dawid Zyla, Christine von Aesch, Mark S. Dillingham, R. Scott Williams, Alessandro A. Sartori

    Science Advances · 2021 · 10.1126/sciadv.abc6381 View paper

  5. Biomolecular solid-state NMR spectroscopy at highest field: The gain in resolution at 1200 MHz

    Callon, M., Malär, A.A., Pfister, S., Rímal, V., Weber, M.E., Wiegand, T., Zehnder, J., Chávez, M., Deb, R., Cadalbert, R., Däpp, A., Fogeron, M.-L., Hunkeler, A., Lecoq, L., Torosyan, A., Zyla, D., Glockshuber, R., Jonas, S., Nassal, M., Ernst, M., Böckmann, A., Meier, B.H.

    bioRxiv · 2021 · 10.1101/2021.03.31.437892 View paper

2020 4 papers

  1. A metabolite binding protein moonlights as a bile‐responsive chaperone

    Changhan Lee, Patrick Betschinger, Kevin Wu, Dawid S Żyła, Rudi Glockshuber, James CA Bardwell

    The EMBO Journal · 2020 · 10.15252/embj.2019104231 View paper

  2. The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

    Jessica J Stanisich, Dawid S Zyla, Pavel Afanasyev, Jingwei Xu, Anne Kipp, Eric Olinger, Olivier Devuyst, Martin Pilhofer, Daniel Boehringer, Rudi Glockshuber

    eLife · 2020 · 10.7554/eLife.60265 View paper

  3. Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA

    Dawid Zyla, Blanca Echeverria, Rudi Glockshuber

    Journal of Biological Chemistry · 2020 · 10.1074/jbc.RA120.014324 View paper

  4. Architecture and function of human uromodulin filaments in urinary tract infections

    Gregor L. Weiss, Jessica J. Stanisich, Maximilian M. Sauer, Chia-Wei Lin, Jonathan Eras, Dawid S. Zyla, Johannes Trück, Olivier Devuyst, Markus Aebi, Martin Pilhofer, Rudi Glockshuber

    Science · 2020 · 10.1126/science.aaz9866 View paper

2019 1 paper

  1. Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria

    Dawid S. Żyła, Andrea E. Prota, Guido Capitani, Rudi Glockshuber

    Journal of Biological Chemistry · 2019 · 10.1074/jbc.RA119.008610 View paper

2017 1 paper

  1. The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod.

    Hospenthal MK, Zyla D, Costa TRD, Redzej A, Giese C, Lillington J, Glockshuber R, Waksman G

    Structure (London, England : 1993) · 2017 · 10.1016/j.str.2017.10.004 View paper